Biochemical and Hematological Changes in Chronic Kidney Failure Patients before and after Dialysis at Sabratha Hospital

Abstract

Chronic kidney failure affects over 10% of the global population, with more than 800 million individuals currently affected. By 2040, it is projected to become the fifth leading cause of lost life years worldwide. This study aimed to evaluate the impact of dialysis on key hematological and Biochemical parameters in 70 patients with chronic kidney failure, focusing on levels of creatinine, urea, white blood cells (WBC), red blood cells (RBC), platelets, and hemoglobin before and after dialysis. The findings revealed that the most affected age group was between 55 and 65 years, representing 42.9% of the patients. Dialysis significantly reduced both urea and creatinine levels (p < 0.05), indicating its effectiveness in removing these waste products. Hemoglobin levels also showed a significant increase post-dialysis, with a positive rank mean of 20.6 compared to a negative rank mean of 18.63 (p < 0.05). However, dialysis did not have a statistically significant effect on WBC, RBC, or platelet levels (p > 0.05). These results demonstrate that while dialysis plays a critical role in reducing urea and creatinine levels and increasing hemoglobin, it has no significant effect on WBC, RBC, or platelet counts in this patient sample.