Hurthle Cell Neoplasm in Thyroid Nodular Swellings: Retrospective Analysis from a Surgical Department in Derna, Libya

الملخص

Hurthle cell neoplasms in the thyroid gland present diagnostic complexities due to varied histology, requiring comprehensive assessment for accurate diagnosis and management. This retrospective study at Derna Hospital, Libya, from 2010 to 2017, involving 225 patients with thyroid nodules, aimed to explore demographic profiles, clinical manifestations, and diagnostic accuracy. Patients underwent thorough evaluations including thyroid function tests, ultrasounds, and fine-needle aspiration cytology, followed by histopathological examination post-surgery. Findings revealed a predominance of normal thyroid function and multinodular goiter in females aged 31-40, with benign Hurthle cell adenomas being common and malignancies rare. Discrepancies between cytodiagnosis and histodiagnosis, notably in inflammatory lesions and papillary carcinoma detection, were observed, guiding tailored surgical interventions such as hemithyroidectomy and total thyroidectomy. While limitations include retrospective design and potential biases, this study underscores the necessity for refined research to enhance diagnostic accuracy and treatment outcomes in thyroid disorders, emphasizing the significance of a comprehensive approach in patient care.